Synapse

The Synapse lineup spans a wide pricing spectrum, split between standard carbon frames, lighter Hi-MOD carbon frames, and the flagship Lab71 tier. The entry points feature mechanical shifting and basic alloy wheels, providing the core frame benefits and tire clearance at a more accessible price. Mid-tier builds represent the sweet spot for many riders, upgrading to electronic groupsets from Shimano or SRAM.

A major dividing line in the catalog is the inclusion of SmartSense. Models designated with this feature include the downtube battery, integrated lights, and a Garmin rear radar. On SRAM-equipped SmartSense builds, this central battery also powers the wireless derailleurs.

At the top end, the Lab71 and Carbon 1 models introduce significant component upgrades, including one-piece carbon cockpits and deep-section Reserve carbon wheels. The Lab71 specifically utilizes a SRAM Red XPLR 1x13 drivetrain with an integrated power meter and a CeramicSpeed bottom bracket. While the flagship models showcase Cannondale's highest integration and lowest weights, reviewers note that the mid-tier Carbon 2 and Carbon 4 builds offer the most compelling value, delivering the same aerodynamic shaping and ride quality despite heavier alloy wheels and standard two-piece cockpits.

Reviewers generally agree that the Synapse delivers an exceptionally smooth and composed ride, effectively muting broken pavement while maintaining enough stiffness for efficient power transfer. The frame's ability to isolate the rider from harsh vibrations is frequently praised, with testers noting it "responds eagerly to steering inputs" (Cycling Weekly) while remaining predictable. On descents and sweeping corners, the bike tracks beautifully, remaining "oblivious to road surfaces" (BikeRadar) that might unsettle a steeper race bike.

However, this emphasis on stability creates a clear tradeoff in agility. While many testers found the handling intuitive, others felt the lengthened wheelbase muted the bike's character. One reviewer noted the geometry "numbed the ride quality" (YouTube), resulting in a sedate feel that lacks the immediate, snappy engagement of racier alternatives.

The integrated SmartSense system is widely considered a massive improvement over the previous generation, with testers appreciating the seamless single-battery operation. Yet, the system adds noticeable weight, which reviewers felt on steep, sustained climbs. Additionally, the 1x gravel-oriented gearing specced on the flagship Lab71 model proved divisive; while excellent for climbing, testers on flatter terrain found themselves "pushing an uncomfortable cadence" (Bicycling) during fast group rides.